After severe myocardial infarction (MI), heart failure results from ischemia, fibrosis, and remodeling.A promising therapy to enhance cardiac function and induce therapeutic angiogenesis via a paracrine mechanism in MI is myoblast sheet transplantation.We hypothesized that in a rat model of MI-induced chronic heart failure, this therapy could be fu
Pheochromocytomas and paragangliomas (PGLs) are rare non-epithelial neuroendocrine neoplasms of the adrenal medulla and extra-adrenal paraganglia ball bearing respectively.Duodenal PGL is quite rare and there are only two previous reports.Herein, we report a case of multiple catecholamines (CAs)-producing PGLs in the middle ear, retroperitoneum, an
Proanthocyanidins (PAs) are the major component of phenolics in apple, but mechanisms involved in PA biosynthesis remain unclear.Here, the relationship between the PA biosynthesis and the expression of genes encoding leucoanthocyanidin reductase (LAR) and anthocyanidin reductase (ANR) was investigated in fruit skin of one apple cultivar and three c
BACKGROUND: Some low molecular weight heparins (LMWHs) prolong survival of cancer patients and inhibit experimental metastasis.The underlying mechanisms are still not clear but it has been suggested that LMWHs (at least in part) limit metastasis by preventing cancer cell-induced destruction of the endothelial glycocalyx.METHODOLOGY/PRINCIPAL FINDIN